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Week 3 NFL odds and computer model picks

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NowWire · AI-assisted reporting summary · September 27, 2026 UTC

The Week 3 NFL schedule features notable matchups, including the first-ever NFL game in Rio de Janeiro, Brazil, where the Dallas Cowboys play as the designated home team against the Baltimore Ravens as 3.5-point underdogs, according to CBS Sports. Other travel-heavy contests include the Chargers visiting the Buffalo Bills as 7-point underdogs, and the Seattle Seahawks visiting the Washington Commanders as 7.5-point favorites. Washington will start Marcus Mariota at quarterback while Jayden Daniels remains out with an elbow injury. [1]

CBS Sports reports that an advanced computer model simulating every game 10,000 times has highlighted several top picks for Week 3. The model projects the Detroit Lions (-6.5) to cover against the New York Jets and the San Francisco 49ers (-8.5) to cover at home against the Arizona Cardinals. [1]

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